Custom Peptides
Cayman Chemical TIrofIbnhydrochLRIde hydr 10mg
A selective VEGFR2 inhibitor (IC50 1 nM) inhibits the proliferation of HUVECs stimulated by FBS and prevents the growth of several established human tumor xenograft models
Cayman Chemical FluspIrIlen 10mg
A non-peptide inhibitor of BACE1 (IC50 239 nM) that demonstrates 10-fold selectivity over BACE2 and 50-fold selectivity over other aspartyl proteases decreases AB in APP-overexpressing cells and transgenic animal models and reduces C99 and sAPPB the two primary APP cleavage products generated by BACE1
Cayman Chemical 1 4dIdeoxy1 4ImInoDArabI 10mg
An ALK inhibitor (IC50s 3 5 10 and 5 4 nM for the wild-type ALKF1174L and ALKR1275Q enzymes respectively) selective for ALK over a panel of 86 kinases at 1000 nM but also inhibits ROS1 and TNK2 (IC50s 8 9 and 5 8 nM respectively) inhibits the proliferation of Ba/F3 cells expressing NPM-ALK or ELM4-ALK fusion proteins (IC50s 84 and 56 nM respectively) as well as several crizotinib-resistant Ba/F3 cells expressing NPM-ALK or ELM4-ALK mutants induces tumor regression in an NCI H2228 NSCLC mouse xenograft model at 10 and 30 mg/kg
Cayman Chemical nIdulafungIn 10mg
An FP receptor agonist and active metabolite of latanoprost selectively binds to the FP receptor (Ki 0 098 UM) over the EP1 EP2 EP3 and EP4 receptors (Kis 2 06 39 667 7 519 and 75 UM respectively) as well as the DP IP and TP receptors (Kis 20 90 and 60 UM respectively) induces phosphoinositide turnover in isolated human ciliary muscle and human trabecular meshwork cells mouse NIH3T3 fibroblasts and rat A7r5 vascular smooth muscle cells which all endogenously express FP receptors (EC50s 124 35 32 and 35 nM respectively) as well as HEK293 cells expressing human ocular FP receptors (EC50 45 7 nM) increases intracellular calcium levels in hEP1-5/293-AEQ17 cells expressing EP1 receptors in an aequorin-based calcium assay (EC50 119 nM) induces contraction of isolated cat iris sphincter smooth muscle (EC50 29 9 nM)
Cayman Chemical 4MethyLMbelIferyl DGala 10mg
A selective TRPA1 blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal (IC50s 14 3 and 18 7 M respectively) 30 mg/kg twice daily in rats attenuates pain-related behavior in models of diabetic hypersensitivity and postoperative pain
Cayman Chemical ThIomuscImol 10mg
A central component of energy storage metabolism and signal transduction in vivo a precursor for ATP and agonist of purinergic receptors
Cayman Chemical MethsuxImIde 10mg
A potent orally bioavailable inhibitor of casein kinase 2 (CK2 Ki 0 38 nM) inhibits proliferation in a panel of cancer cell lines that overexpress CK2 and prevents tumor growth of breast and pancreatic cancer cell xenografts in mice
Cayman Chemical CGP 54626hydrochlorIde 10mg
PGI2 is an unstable COX metabolite detected first in vascular endothelial cells 502443933 It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 value of 5 nM 4375 PGI2 is stable in basic buffers (pH8) but it is rapidly hydrolyzed to 6-keto PGF1a in neutral or acidic solutions The half-life is short both in vivo and in vitro ranging from 30 seconds to a few minutes PGI2 is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension 5466
Cayman Chemical nsamItocIn P-3 10mg
A FAHFA consisting of palmitoleic acid esterified at the 12th carbon of stearic acid significantly elevated in serum of glucose tolerant AG4OX mice may be a bioactive lipid with roles in metabolic syndrome and inflammation
Cayman Chemical Tnactum patnum Aglabn 10mg
An NSAID that non-selectively inhibits human COX-1 and -2 with IC50 values of 0 35 and 0 82 UM respectively also inhibits aldo-keto reductases (e g IC50 2 39 UM for human aldose reductase)
Cayman Chemical 1 2DImyrIstoylsnglycero3 10mg
An orally available selective VEGFR inhibitor (IC50s 0 21 0 16 and 0 24 nM for VEGFR1 VEGFR2 and VEGFR3 respectively) also inhibits c-Kit and PDGFRB (IC50s 1 63 and 1 72 nM respectively)
Cayman Chemical PyrroloquInolIn quInon 10mg
An antimalarial drug used in the treatment of persistent liver forms of P vivax or P ovale infection for its ability to kill late-stage gametocytes and hypnozoites
Cayman Chemical 2 5-dIdeoxy AdenosIn 10mg
An mGluR5 PAM induces calcium mobilization in HEK293 cells expressing human mGluR5 (EC50 260 nM) selective for mGluR5 over mGluR1-4 and mGluR6-8 at 10 M reverses amphetamine-induced hyperlocomotion in rats (ED50 23 mg/kg) indicating antipsychotic-like activity increases levels of c-fos and expression of BDNF Arc/Arg3 1 syntaxin 1A and PSD-95 in the hippocampus in the BACHD mouse model of Huntingtons disease at 3 mg/kg improves object location memory in the novel object location test and associative memory in the cued fear conditioning test in the BACHD mouse model at 3 mg/kg