Custom Peptides
Cayman Chemical NBenzylacetamIdInhydrobro 10mg
A potent inhibitor of iNOS (IC50 = 0.20 μM), with over 1,000-fold selectivity compared to eNOS (IC50 = 350 μM)
Cayman Chemical DIhydrodaIdzeIn 10mg
An active, estrogenic metabolite of daidzein; has vasodilatory action on rat isolated aortic rings at 1 UG/ml; stimulates the estrogen receptor-dependent growth of breast cancer MCF-7 cells at micromolar concentrations
Cayman Chemical Compound 401 10mg
A dual inhibitor of mTOR and DNA-PK (IC50s = 0.28 and 5.3 µM, respectively); selective for DNA-PK and mTOR over PI3K, ATM, and ATR (IC50s = >100 µM for all); inhibits phosphorylation of the mTOR targets S6K1 and Akt in Rat-1 fibroblasts and in M059J glioma cells that lack DNA-PK at 10 µM; inhibits proliferation of TSC1-/- MEFs (IC50 = 2 µM) but not TSC1+/+ MEFs; induces apoptosis in TSC1-/- MEFs
Cayman Chemical DIroxImel Fumarate 10mg
A prodrug form of monomethyl fumarate; undergoes esterase cleavage in the gut to release monomethyl fumarate
Cayman Chemical N6-CyclopentyladenosIn 10mg
A selective agonist at A1R (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively)
Cayman Chemical 1PalmItoyl2Stearoyl3Oleo 10mg
A triacylglycerol; has been detected in RAW 264.7 cells by neutral loss MS; increased serum levels are a potential biomarker for NAFLD
Cayman Chemical 1Oleoyl2PalmItoylracglyc 10mg
A diacylglycerol; enhances the inhibition of superoxide anion production by cytochalasin B at 10 µM
Cayman Chemical GInkgolIde C 10mg
A selective PAF receptor antagonist (IC50 = 37.6 μM); increases lipolysis and inhibits adipogenesis in adipocytes via the activated AMPK pathway
Cayman Chemical Pperaqun 10mg
An antimalarial agent; a bis-quinoline compound; inhibits the ex vivo growth of P. falciparum isolates from malaria-infected patients (IC50s = 11.8-217.3 nM)
Cayman Chemical Gunylyl ImIdodIphosphATlI 10mg
A nonhydrolyzable GTP analog that binds to and irreversibly activates G proteins; potently stimulates adenylate cyclase
Cayman Chemical KnosamInhydrochlorIde 10mg
An antibiotic that can inhibit cell wall synthesis in plant-pathogenic oomycetes (MIC = 25 UG/ml for P. medicaginis M2913) and certain fungi as well as some bacterial species (MIC = 400 UG/ml for S. aureus)
Cayman Chemical Fz721trIfluoroACTAte salt 10mg
A peptide antagonist of the FZD7 receptor (IC50 = 100 nM); inhibits Wnt3a-induced β-catenin signaling in a reporter assay using HEK293 cells; reduces the number of Lrg5-positive cells and the mRNA encoding Ash-2 and Axin2 and increases mRNA encoding Muc2 in primary mouse intestinal organoids at 100 µM
Cayman Chemical VardenafIlhydroCLOrID hyd 10mg
An inhibitor of PDE5 (IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM); selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively); improves erectile dysfunction in a rat model of acute arteriogenic erectile dysfunction; reduces the latency to mount and increases the frequency of mounting in mice after chronic treatment at 2 mg/kg for five weeks
Cayman Chemical 7keto DehydroepIndrosTRon 10mg
An analytical reference standard categorized as a steroid metabolite of dehydroepiandrosterone; reduces ethanol consumption without the hormone-generating effects of dehydroepiandrosterone in rats; intended for research and forensic applications
Cayman Chemical TIpIracIlhydrochlorIde 10mg
A thymidine phosphorylase inhibitor (IC50 = 35 nM); selective for thymidine phosphorylase over UPase, TK, OPRTase, and DPD (IC50s = > 1,000 µM for all); inhibits SARS-CoV-2 endoribonuclease nsp15 (IC50 = 7.5 µM); reduces the levels of SARS-CoV-2 spike glycoprotein in SARS-CoV-2-infected A549 cancer cells at 50 µM; prevents trifluorothymidine metabolism in human liver extracts at 1 µM; increases the plasma levels and potentiates the cytotoxicity of trifluorothymidine in an AZ-521 gastric carcinoma mouse xenograft model at an equimolar dose